A multiwell assay for inhibitors of phosphatidylinositol-3-kinase and the identification of natural product inhibitors.
作者信息
Frew T, Powis G, Berggren M, Abraham R T, Ashendel C L, Zalkow L H, Hudson C, Qazia S, Gruszecka-Kowalik E, Merriman R
机构信息
Arizona Cancer Center, University of Arizona, Tucson 85724.
出版信息
Anticancer Res. 1994 Nov-Dec;14(6B):2425-8.
PMID:7872663
Abstract
A convenient and reliable multisample assay for the screening of inhibitors of the growth factor signalling enzyme phosphatidylinositol-3-kinase (PtdIns-3-K) has been developed. Four natural product inhibitors of Ptdlns-3-K have been identified with IC50 values for hypericin 0.18 microM, emodin 3.3 microM, asperuloside 2.0 microM and uttronin A 1.1 microM.
摘要
Zotero 插件