Proposed molecular and cellular mechanism for aminoglycoside ototoxicity.
作者信息
Hutchin T, Cortopassi G
机构信息
Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Los Angeles 90033.
出版信息
Antimicrob Agents Chemother. 1994 Nov;38(11):2517-20. doi: 10.1128/AAC.38.11.2517.
Abstract
摘要
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Mitochondrial diseases: genotype versus phenotype.线粒体疾病：基因型与表型
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A molecular basis for human hypersensitivity to aminoglycoside antibiotics.人类对氨基糖苷类抗生素超敏反应的分子基础。
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Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death.Bcl-2在体内与一个保守的同源物Bax形成异二聚体，后者会加速程序性细胞死亡。
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