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Proposed molecular and cellular mechanism for aminoglycoside ototoxicity.

作者信息

Hutchin T, Cortopassi G

机构信息

Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Los Angeles 90033.

出版信息

Antimicrob Agents Chemother. 1994 Nov;38(11):2517-20. doi: 10.1128/AAC.38.11.2517.

DOI:10.1128/AAC.38.11.2517
PMID:7872740
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC188234/
Abstract
摘要

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本文引用的文献

1
Mitochondrial diseases: genotype versus phenotype.线粒体疾病：基因型与表型
Trends Genet. 1993 Apr;9(4):128-33. doi: 10.1016/0168-9525(93)90207-x.
2
A molecular basis for human hypersensitivity to aminoglycoside antibiotics.人类对氨基糖苷类抗生素超敏反应的分子基础。
Nucleic Acids Res. 1993 Sep 11;21(18):4174-9. doi: 10.1093/nar/21.18.4174.
3
Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death.Bcl-2在体内与一个保守的同源物Bax形成异二聚体，后者会加速程序性细胞死亡。
Cell. 1993 Aug 27;74(4):609-19. doi: 10.1016/0092-8674(93)90509-o.
4
NADH- and NADPH-dependent lipid peroxidation in bovine heart submitochondrial particles. Dependence on the rate of electron flow in the respiratory chain and an antioxidant role of ubiquinol.牛心脏亚线粒体颗粒中依赖NADH和NADPH的脂质过氧化作用。对呼吸链中电子流动速率的依赖性以及泛醇的抗氧化作用。
Biochem J. 1980 Dec 15;192(3):853-60. doi: 10.1042/bj1920853.
5
Sequence and organization of the human mitochondrial genome.人类线粒体基因组的序列与组织
Nature. 1981 Apr 9;290(5806):457-65. doi: 10.1038/290457a0.
6
Identification of the paromomycin-resistance mutation in the 15 S rRNA gene of yeast mitochondria.酵母线粒体15S rRNA基因中对巴龙霉素耐药性突变的鉴定。
J Biol Chem. 1982 May 25;257(10):5921-8.
7
Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria.牛心线粒体NADH脱氢酶产生超氧阴离子。
Biochem J. 1980 Nov 1;191(2):421-7. doi: 10.1042/bj1910421.
8
Antibiotics: a tool in the search for the degree of autonomy of mitochondria in higher animals.抗生素：探索高等动物线粒体自主程度的一种工具。
Symp Soc Exp Biol. 1970;24:181-99.
9
Structure-activity relationships among the aminoglycoside antibiotics: role of hydroxyl and amino groups.氨基糖苷类抗生素的构效关系：羟基和氨基的作用
Antimicrob Agents Chemother. 1973 Oct;4(4):402-9. doi: 10.1128/AAC.4.4.402.
10
Fidelity of protein synthesis with chicken embryo mitochondrial and cytoplasmic ribosomes.
Biochemistry. 1974 Jan 29;13(3):572-7. doi: 10.1021/bi00700a026.