Fawcett J
Rush-Presbyterian-St Luke's Medical Center, Chicago, Illinois.
Br J Psychiatry Suppl. 1994 Dec(26):37-41.
Although most studies of chronic depression show significant improvements with antidepressants versus placebo, the average Hamilton Depression Rating Scale results attained in the active-treatment group range between 10 and 14, suggesting that many patients only partially responded and failed to reach premorbid levels of symptom remission. Studies on the fate of these patients suggest that they are much more vulnerable to relapse, work impairment and suicide. Thus, partial response may be one form of treatment resistance, falling between total failure of response in a minority of patients, and a tendency to relapse or recur despite adequate maintenance treatment. Further study is needed to address the problem of improving the quality of response and attempting to reduce the detrimental effects of depressive illness in terms of relapse and recurrence.
尽管大多数关于慢性抑郁症的研究表明，与安慰剂相比，抗抑郁药能带来显著改善，但积极治疗组的汉密尔顿抑郁量表平均得分在10至14之间，这表明许多患者只是部分有反应，未能达到病前症状缓解水平。对这些患者预后的研究表明，他们更容易复发、出现工作障碍和自杀。因此，部分反应可能是治疗抵抗的一种形式，介于少数患者完全无反应和尽管维持治疗充分仍有复发倾向之间。需要进一步研究来解决提高反应质量的问题，并试图减少抑郁症在复发和再发方面的有害影响。
