de Miguel Martínez I, Ramos Macías A, Muñoz Bellido J L, del Cañizo Alvarez A
Servicio de Microbiología, Hospital Insular de Las Palmas de Gran Canaria.
Acta Otorrinolaringol Esp. 1994 Nov-Dec;45(6):433-6.
The present study compares two therapy protocols in 40 children with recurrent tonsillitis. Twenty of them were randomly treated with penicillin, and the remaining 20 received penicillin + metronidazole. Clinical and microbiological assessment of the results was made. The association of penicillin and metronidazole was most efficient, probably due to its activity against Streptococus pyogenes and anaerobic betalactamase-producing bacterias. The high failure rate in the penicillin group states the necessity to change the therapy with this antibiotic in the treatment of childhood recurrent tonsillitis.
本研究比较了40例复发性扁桃体炎患儿的两种治疗方案。其中20例随机接受青霉素治疗，其余20例接受青霉素+甲硝唑治疗。对结果进行了临床和微生物学评估。青霉素和甲硝唑联合使用最为有效，这可能是由于其对化脓性链球菌和产β-内酰胺酶厌氧菌的活性。青霉素组的高失败率表明在儿童复发性扁桃体炎治疗中需要改变这种抗生素的治疗方法。
