A case of slow variant bisalbuminmia: study of its composition in amino acids.

The authors report an observation of slow variant bisalbuminemia. After electrophoretic separation of two varieties, the amino acid chromatographic analysis has permitted them to show that in the slow variant the molecule of albumin has undergone a substitution of several glutamic acid residues by lysine and of several alanine residues by proline. Such an alteration poses the problem of its effect on the antigenic specificity of the molecule and that of its mechanism of production.