Giménez Fernández J, Arderiu Freixa A, Bada Ainsa J L
Med Clin (Barc). 1979 Dec 15;73(10):451-5.
A general review of bisalbuminemia is presented. Besides congenital bisalbuminemia there is an acquired form of bisalbuminemia that appears following treatment with high dosis of penicillin and cephalosporin, or in cases of acute pancreatitis after the development of a pancreatic pseudocyst. There is one type of abnormal albumin that migrates faster than normal albumin (rapid variant) and another type that is slower (slow variant). Different subtypes of each one have been recognized. There is no immunological difference between normal albumin and the variants. From a clinical point of view, bisalbuminemia per se does not cause any observable alterations. This is an important finding, however, because of the possibility that some physiologic or pharmacologic substances may not be bound to the abnormal variants as well as to normal albumin. When bisalbuminemia appears following an episode of pancreatitis it may be indicative of a pancreatic pseudocyst.
本文对双白蛋白血症进行了综述。除先天性双白蛋白血症外，还有一种获得性双白蛋白血症，它出现在高剂量青霉素和头孢菌素治疗后，或急性胰腺炎并发胰腺假性囊肿的情况下。有一类异常白蛋白迁移速度比正常白蛋白快（快速变体），另一类则较慢（慢速变体）。已识别出每一类的不同亚型。正常白蛋白与变体之间没有免疫学差异。从临床角度来看，双白蛋白血症本身不会引起任何可观察到的改变。然而，这是一个重要发现，因为某些生理或药理物质可能与异常变体的结合不如与正常白蛋白的结合紧密。胰腺炎发作后出现双白蛋白血症可能提示胰腺假性囊肿。
