Laporte M, Heenen M
Department of Dermatology, Hôpital Erasme, Brussels, Belgium.
Dermatology. 1994;189(4):340-3. doi: 10.1159/000246875.
In mouse epidermis keratinocytes of the basal layer seem to belong to 3 different subpopulations: stem cells, transit cells and postmitotic cells. Each subpopulation assumes a specific role in epidermal homeostasis. Recent data tend to display a similar heterogeneity among basal keratinocytes in human epidermis. This concept opens the door to an integrated understanding of epidermal renewal but also suggests new hypotheses in pathogenesis. Psoriasis, a typical example of epidermal hyperplasia, is considered from this point of view.
在小鼠表皮中，基底层的角质形成细胞似乎属于3种不同的亚群：干细胞、过渡细胞和有丝分裂后细胞。每个亚群在表皮稳态中都发挥着特定作用。最近的数据显示，人类表皮的基底角质形成细胞之间也存在类似的异质性。这一概念为全面理解表皮更新打开了大门，同时也为发病机制提出了新的假设。本文从这一角度对银屑病这一典型的表皮增生性疾病进行了探讨。
