Department of Dermatology, Hôpital Universitaire Erasme, Brussels, Belgium.
Cell Prolif. 2010 Jun;43(3):321-5. doi: 10.1111/j.1365-2184.2010.00672.x.
Although there have been major advances in understanding immunopathogenesis of psoriasis, the basic processes causing psoriatic morphology remain to be identified.
Our group has designed a systematic review of studies (1962-2009) on keratinocyte kinetics in psoriasis. We obtained data from MEDLINE, PubMed, Current Contents, reference lists and specialist textbooks. A general equation for evolution of the differentiated epidermis has been analysed. Necessary conditions for observed qualitative change in homeostasis between normal skin and established psoriatic lesions were determined.
Increase in the number of cell divisions (or imbalance in symmetric division rates of committed progenitor cells) and/or decrease in physiological apoptosis in the germinative compartment, together with feedback loops that limit thickening of the skin, are required to generate psoriatic morphology, that is, to increase the absolute size but decrease relative size of the differentiated cell compartment with respect to the germinative compartment.
尽管人们对银屑病的免疫发病机制已有了深入的了解，但导致银屑病形态学的基本过程仍有待确定。
我们小组对银屑病角朊细胞动力学的研究（1962-2009 年）进行了系统综述。我们从 MEDLINE、PubMed、Current Contents、参考文献列表和专业教科书获取数据。对分化表皮的进化进行了一般方程分析。确定了在正常皮肤和已建立的银屑病病变之间的体内平衡中观察到的定性变化的必要条件。
增加细胞分裂的数量（或对称分裂率失衡的定向祖细胞）和/或减少有丝分裂中胚层的生理凋亡，与限制皮肤增厚的反馈回路一起，是产生银屑病形态学所必需的，即增加分化细胞区室相对于有丝分裂中胚层的绝对大小，但减小相对大小。
