Karvonen S L, Räsänen L, Cunliffe W J, Holland K T, Karvonen J, Reunala T
Department of Dermatology, University Hospitals of Oulu, Finland.
Dermatology. 1994;189(4):344-9. doi: 10.1159/000246876.
Increased hypersensitivity reactions to Propionibacterium acnes may be involved in the pathogenesis of severe acne.
To study delayed and immediate hypersensitivity reactions to P. acnes in patients with severe nodular acne (SNA) and acne fulminans (AF).
We performed lymphocyte stimulation and skin tests for P. acnes antigens on 11 patients with SNA and 7 patients with AF.
The patients with SNA had similar mean lymphocyte stimulation indices (mean 13.96, SD 8.6) to P. acnes during active disease as had healthy controls (12.63, SD 6.46). After the treatment the mean stimulation index was significantly elevated (23.47, SD 13.84, p = 0.006). A similar increase occurred in the patients with AF (mean 17.04, SD 5.74, and 33.42, SD 27.17, respectively). Two of 7 patients with SNA and 3 of the 7 patients with AF but none of the 10 control subjects showed positive 48-hour intradermal tests to P. acnes.
Specific cell-mediated immunity to P. acnes increases during the course of severe inflammatory acne.
对痤疮丙酸杆菌超敏反应增加可能参与重度痤疮的发病机制。
研究重度结节性痤疮（SNA）和暴发性痤疮（AF）患者对痤疮丙酸杆菌的迟发型和速发型超敏反应。
我们对11例SNA患者和7例AF患者进行了针对痤疮丙酸杆菌抗原的淋巴细胞刺激试验和皮肤试验。
SNA患者在疾病活动期对痤疮丙酸杆菌的平均淋巴细胞刺激指数（均值13.96，标准差8.6）与健康对照者（12.63，标准差6.46）相似。治疗后平均刺激指数显著升高（23.47，标准差13.84，p = 0.006）。AF患者也出现了类似的升高（分别为均值17.04，标准差5.74和33.42，标准差27.17）。7例SNA患者中有2例、7例AF患者中有3例，但10例对照受试者中无一人对痤疮丙酸杆菌的48小时皮内试验呈阳性。
在重度炎症性痤疮病程中，对痤疮丙酸杆菌的特异性细胞介导免疫增强。
