Avellana-Adalid V, Rebel G, Caron M, Cornillot J D, Bladier D, Joubert-Caron R
Laboratoire de Biochimie et Technologie des Protéines, Université Paris-Nord, UFR SMBH Léonard de Vinci, Bobigny, France.
Glycoconj J. 1994 Aug;11(4):286-91. doi: 10.1007/BF00731200.
The distribution of a 14.4 kDa S-type lectin was examined in murine neuroblastoma cells, either undifferentiated or after differentiation induced by dibutyryl-cyclic adenosine monophosphate. In undifferentiated cells the immunoreactivity was detected extracellularly, associated with the plasma membrane and in bulges released into the extracellular milieu. Important modifications of the lectin localization were associated with the differentiation process that induced an increased cytosolic expression and a decreased externalization. Possible functions for the lectin expressed intracellularly in the differentiated cells are also considered.
研究了一种14.4 kDa S型凝集素在小鼠神经母细胞瘤细胞中的分布，这些细胞要么未分化，要么在经二丁酰环磷酸腺苷诱导分化后进行观察。在未分化细胞中，免疫反应性在细胞外被检测到，与质膜相关，并存在于释放到细胞外环境中的凸起中。凝集素定位的重要变化与分化过程相关，分化过程导致胞质表达增加和外化减少。还考虑了分化细胞中细胞内表达的凝集素的可能功能。
