丙二醛在乙醛存在下与脱氧核糖核苷的反应。

Reaction of malondialdehyde with deoxyribonucleosides in the presence of acetaldehyde.

作者信息

Ohya T

机构信息

Faculty of Pharmaceutical Sciences, Josai University, Saitama, Japan.

出版信息

Biol Pharm Bull. 1994 Oct;17(10):1411-3. doi: 10.1248/bpb.17.1411.

DOI:10.1248/bpb.17.1411

PMID:7874067

Abstract

The reactivity of malondialdehyde (MDA) with deoxyribonucleosides in the presence of acetaldehyde (AA) was investigated. Although MDA is known to be reactive towards deoxyguanosine (GdR), deoxyadenosine (AdR) and deoxycytidine (CdR) under acidic conditions, MDA had only slight reactivity towards GdR under physiological pH. However, when AA was present, MDA exhibited much higher reactivity towards GdR, and a reaction with AdR also took place.

摘要

研究了在乙醛（AA）存在下丙二醛（MDA）与脱氧核苷的反应活性。虽然已知MDA在酸性条件下对脱氧鸟苷（GdR）、脱氧腺苷（AdR）和脱氧胞苷（CdR）具有反应活性，但在生理pH值下MDA对GdR的反应活性较低。然而，当存在AA时，MDA对GdR表现出更高的反应活性，并且也发生了与AdR的反应。