Boyle M B, Heslip L A
Department of Ob/Gyn, University of Texas Medical Branch, Galveston 77555-1062.
Recept Channels. 1994;2(3):249-53.
The mechanisms responsible for the onset of vigorous contractile activity in uterine muscle at the time of parturition, reversing the obligatory quiescence of pregnancy, remain poorly understood. We here describe the expression in myometrium from human and from timed-pregnant rats of an mRNA species encoding a voltage-sensitive sodium channel. The apparent concentration of this mRNA species, as measured by reverse-transcription polymerase chain reaction, underwent an approximately four-fold decline between mid-gestation and term. These results complement earlier reports of increased sodium current expression in mid- and late pregnancy and further support a role for smooth muscle sodium current in late pregnancy and/or labor.
分娩时子宫肌出现强烈收缩活动，打破孕期的强制性静息状态，其机制仍知之甚少。我们在此描述了一种编码电压敏感性钠通道的mRNA在人子宫肌层以及妊娠不同阶段大鼠子宫肌层中的表达情况。通过逆转录聚合酶链反应测定，该mRNA的表观浓度在妊娠中期到足月之间下降了约四倍。这些结果补充了早期关于妊娠中期和晚期钠电流表达增加的报道，并进一步支持了平滑肌钠电流在妊娠晚期和/或分娩中的作用。
