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液泡分选：寻找难以捉摸的受体

Vacuolar sorting. Tracking down an elusive receptor.

作者信息

Chapman R E

机构信息

MRC Laboratory of Molecular Biology, Cambridge, UK.

出版信息

Curr Biol. 1994 Nov 1;4(11):1019-22. doi: 10.1016/s0960-9822(00)00231-1.

DOI:10.1016/s0960-9822(00)00231-1
PMID:7874484
Abstract

The receptor that sorts carboxypeptidase Y for transport to the vacuole in yeast has recently been identified; how vacuolar sorting is regulated is far from understood, but an intriguing model has been proposed.

摘要

最近已鉴定出在酵母中负责将羧肽酶Y分拣运输至液泡的受体；液泡分拣是如何被调控的目前还远未明确，但已有人提出了一个有趣的模型。

相似文献

1
Vacuolar sorting. Tracking down an elusive receptor.液泡分选：寻找难以捉摸的受体
Curr Biol. 1994 Nov 1;4(11):1019-22. doi: 10.1016/s0960-9822(00)00231-1.
2
Novel protein kinase/phosphatidylinositol 3-kinase complex essential for receptor-mediated protein sorting to the vacuole in yeast.新型蛋白激酶/磷脂酰肌醇3激酶复合物对酵母中受体介导的蛋白分选至液泡至关重要。
Cold Spring Harb Symp Quant Biol. 1995;60:157-70. doi: 10.1101/sqb.1995.060.01.019.
3
The sorting receptor for yeast vacuolar carboxypeptidase Y is encoded by the VPS10 gene.酵母液泡羧肽酶Y的分选受体由VPS10基因编码。
Cell. 1994 May 20;77(4):579-86. doi: 10.1016/0092-8674(94)90219-4.
4
VPS27 controls vacuolar and endocytic traffic through a prevacuolar compartment in Saccharomyces cerevisiae.VPS27通过酿酒酵母中的前液泡区室控制液泡和内吞运输。
J Cell Biol. 1995 Nov;131(3):603-17. doi: 10.1083/jcb.131.3.603.
5
Retrieval of resident late-Golgi membrane proteins from the prevacuolar compartment of Saccharomyces cerevisiae is dependent on the function of Grd19p.从酿酒酵母的液泡前区室中回收晚期高尔基体膜驻留蛋白取决于Grd19p的功能。
J Cell Biol. 1998 Feb 9;140(3):577-90. doi: 10.1083/jcb.140.3.577.
6
Mutational analysis of the vacuolar sorting signal of procarboxypeptidase Y in yeast shows a low requirement for sequence conservation.酵母中羧肽酶Y原的液泡分选信号的突变分析表明对序列保守性的要求较低。
J Biol Chem. 1996 Jan 12;271(2):841-6. doi: 10.1074/jbc.271.2.841.
7
Vps10p cycles between the late-Golgi and prevacuolar compartments in its function as the sorting receptor for multiple yeast vacuolar hydrolases.Vps10p在晚期高尔基体和前液泡区室之间循环，作为多种酵母液泡水解酶的分选受体发挥作用。
J Cell Biol. 1996 May;133(3):529-41. doi: 10.1083/jcb.133.3.529.
8
VPS21 controls entry of endocytosed and biosynthetic proteins into the yeast prevacuolar compartment.VPS21控制内吞蛋白和生物合成蛋白进入酵母前液泡区室。
Mol Biol Cell. 2000 Feb;11(2):613-26. doi: 10.1091/mbc.11.2.613.
9
A subset of yeast vacuolar protein sorting mutants is blocked in one branch of the exocytic pathway.酵母液泡蛋白分选突变体的一个亚群在胞吐途径的一个分支中受阻。
J Cell Biol. 2002 Jan 21;156(2):271-85. doi: 10.1083/jcb.200109077.
10
Compartment acidification is required for efficient sorting of proteins to the vacuole in Saccharomyces cerevisiae.在酿酒酵母中，区室酸化是蛋白质有效分选至液泡所必需的。
J Biol Chem. 1992 Feb 15;267(5):3416-22.

引用本文的文献

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BMC Mol Cell Biol. 2020 Oct 7;21(1):70. doi: 10.1186/s12860-020-00314-w.
2
Molecular cloning and biochemical characterization of a Drosophila phosphatidylinositol-specific phosphoinositide 3-kinase.果蝇磷脂酰肌醇特异性磷脂酰肌醇-3激酶的分子克隆及生化特性分析
Biochem J. 1997 Feb 1;321 ( Pt 3)(Pt 3):849-56. doi: 10.1042/bj3210849.
3
The cytoplasmic tail domain of the vacuolar protein sorting receptor Vps10p and a subset of VPS gene products regulate receptor stability, function, and localization.
液泡蛋白分选受体Vps10p的胞质尾域和VPS基因产物的一个子集调节受体的稳定性、功能和定位。
Mol Biol Cell. 1995 Sep;6(9):1089-102. doi: 10.1091/mbc.6.9.1089.
4
Yeast aminopeptidase I is post-translationally sorted from the cytosol to the vacuole by a mechanism mediated by its bipartite N-terminal extension.
EMBO J. 1995 Nov 15;14(22):5476-84. doi: 10.1002/j.1460-2075.1995.tb00234.x.
5
A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system.
EMBO J. 1995 Jul 17;14(14):3339-48. doi: 10.1002/j.1460-2075.1995.tb07340.x.