正常衰老过程中下丘脑-垂体-肾上腺皮质轴对毒扁豆碱的反应增强。
Enhanced hypothalamic-pituitary-adrenocortical axis responses to physostigmine in normal aging.
作者信息
Peskind E R, Raskind M A, Wingerson D, Pascualy M, Thal L J, Dobie D J, Veith R C, Dorsa D M, Murray S, Sikkema C
机构信息
Geriatric Research, Education and Clinical Center, Seattle, Veterans Affairs Medical Center.
出版信息
J Gerontol A Biol Sci Med Sci. 1995 Mar;50(2):M114-20. doi: 10.1093/gerona/50a.2.m114.
BACKGROUND
The purpose of this study was to determine the effects of normal human aging on the hypothalamic-pituitary-adrenocortical (HPA) axis response to the centrally active cholinesterase inhibitor physostigmine. This drug stimulates the HPA axis at a suprapituitary level by increasing central nervous system (CNS) cholinergic activity.
METHODS
Plasma ACTH, beta-endorphin (beta E) and cortisol responses to a 10-minute infusion of physostigmine (.0125 mg/kg) were compared between groups of 10 normal older subjects (71 +/- 2 years [mean +/- SEM]) and 9 normal young subjects (27 +/- 2 years). Plasma physostigmine concentrations were measured to assess the comparability of the pharmacologic stimulus between groups.
RESULTS
Endocrine responses were substantially greater in older subjects than young subjects for ACTH (p < .01), beta E (p < .01) and cortisol (p < .01). Plasma physostigmine concentrations did not differ between older and young subjects.
CONCLUSION
This study demonstrated increased HPA axis responsivity to a CNS cholinergic stimulus in normal human aging.
背景
本研究的目的是确定正常人类衰老对下丘脑 - 垂体 - 肾上腺皮质（HPA）轴对中枢活性胆碱酯酶抑制剂毒扁豆碱反应的影响。该药物通过增加中枢神经系统（CNS）胆碱能活性，在垂体上水平刺激HPA轴。
方法
比较了10名正常老年受试者（71±2岁[平均值±标准误]）和9名正常年轻受试者（27±2岁）对10分钟输注毒扁豆碱（0.0125mg/kg）的血浆促肾上腺皮质激素（ACTH）、β-内啡肽（βE）和皮质醇反应。测量血浆毒扁豆碱浓度以评估两组间药理刺激的可比性。
结果
老年受试者的促肾上腺皮质激素（p <.01）、β-内啡肽（p <.01）和皮质醇（p <.01）的内分泌反应比年轻受试者大得多。老年和年轻受试者之间的血浆毒扁豆碱浓度没有差异。
结论
本研究表明，在正常人类衰老过程中，HPA轴对中枢胆碱能刺激的反应性增加。
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