Vincent A, Baruch P, Pourcher E, Vincent E P
Département de psychiatrie, Hôpital de l'Enfant-Jésus, Université Laval-Robert Giffard, Québec.
Can J Psychiatry. 1994 Nov;39(9):545-50. doi: 10.1177/070674379403900906.
This article reviews the main clinical indicators linking the basal nuclei to obsessive compulsive disorder (OCD). Various pathologies associated with lesions of the basal nuclei are examined, followed by a review of neuropharmacological, brain imaging and psychosurgical studies. Once the role of the neostriatum in ritualistic behaviours has been clarified, the symptoms of OCD are interpreted based on the hypothesis of a lesion of the striato-orbito-frontal loop.
本文综述了将基底核与强迫症(OCD)联系起来的主要临床指标。研究了与基底核损伤相关的各种病理学,随后回顾了神经药理学、脑成像和精神外科研究。一旦新纹状体在仪式行为中的作用得以阐明,强迫症的症状将基于纹状体 - 眶额环路损伤的假说进行解读。