Modell J G, Mountz J M, Beresford T P
Department of Psychiatry, University of Michigan Alcohol Research Center, Ann Arbor 48109-0116.
J Neuropsychiatry Clin Neurosci. 1990 Spring;2(2):123-44. doi: 10.1176/jnp.2.2.123.
The authors explore the possible role of basal ganglia/limbic striatal and thalamocortical circuits in craving and loss of control in alcohol abuse and dependence. Alcoholics may suffer from a defect in the neuronal systems within basal ganglia/limbic striatal and thalamocortical neuronal circuits, especially within the striatoaccumbal-ventral pallidal portion of this circuit or its dopaminergic nigrotegmental modulation. Alcoholic craving may result from a neurophysiologically driven obsession resulting from overactivity within the fronto-thalamic neuronal loop, and loss of control of alcohol consumption may be a neurophysiologically driven compulsion resulting from further impairment of the basal ganglia/limbic striatal portion of this circuit caused by the acute dopaminergic effects of intoxication.
作者探讨了基底神经节/边缘纹状体和丘脑皮质回路在酒精滥用和依赖中的渴望及失控现象中可能发挥的作用。酗酒者可能在基底神经节/边缘纹状体和丘脑皮质神经元回路内的神经系统存在缺陷，特别是在该回路的纹状体伏隔核 - 腹侧苍白球部分或其多巴胺能黑质被盖调节方面。酒精渴望可能源于额 - 丘脑神经元回路过度活跃所导致的神经生理学驱动的强迫观念，而饮酒失控可能是由中毒的急性多巴胺能效应导致该回路的基底神经节/边缘纹状体部分进一步受损所引发的神经生理学驱动的强迫行为。
