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[孕妇缺铁性贫血筛查中血红蛋白浓度界值的研究]

[A study on the boundary value of hemoglobin concentration for screening iron deficiency anemia in pregnant women].

作者信息

Gao S, Zhang J, Wang W

机构信息

Tiantan Hospital, Beijing.

出版信息

Zhonghua Liu Xing Bing Xue Za Zhi. 1994 Dec;15(6):339-42.

PMID:7874701
Abstract

To evaluate whether a pregnant woman is in anemia or there exist the needs to replenish iron is usually based on the measurement of hemoglobin (HB) concentration, because the evaluation of iron nutritional status has not yet been used widely in our country. Blood specimens were collected from 258 pregnant women, and concentrations of Hb, serum ferritin (SF) and free erythrocyte protoporphyrin (FEP) were determined to find out a reasonably boundary value of Hb concentration from the two different ones set by our country and WHO, respectively, and the one averaged the former two, i.e, 100g/L, 110g/L and 105g/L. False positivity and false negativity in diagnosis of iron deficiency anemia (IDA) for pregnant women were evaluated based on the measurement of SF and FEP concentrations as gold standards. Results showed that the optimal Hb concentration for preliminary diagnosis of IDA was 105g/L with maximizing Yorden index.

摘要

评估孕妇是否贫血或是否有补铁需求通常基于血红蛋白(HB)浓度的测定,因为我国尚未广泛应用铁营养状况评估。收集了258名孕妇的血样,测定了HB、血清铁蛋白(SF)和游离红细胞原卟啉(FEP)的浓度,以分别从我国和世界卫生组织设定的两个不同的HB浓度值中找出一个合理的界限值,以及将前两者平均后的界限值,即100g/L、110g/L和105g/L。以SF和FEP浓度测定作为金标准,评估孕妇缺铁性贫血(IDA)诊断中的假阳性和假阴性。结果显示,以约登指数最大化为标准,IDA初步诊断的最佳HB浓度为105g/L。

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