[Observation on prevention of hepatitis B virus transmission from mother to baby by hepatitis B vaccine].

Forty-two new-born infants whose mothers had been given HBV vaccine before marriage were undergone medical examination for six years. The results showed that the six-month seroconversion rates of anti-HBs among those infants, whose mothers had been immunized successfully, were 90.00% (9/10), and no one was infected by HBV. But the rates of those infants whose mothers were found to be HBsAg(+) and HBsAg/HBeAg(+) before or after marriage were 20.00% (2/10) and 18.18% (4/22), respectively, being much lower than the former. The rates of HBsAg(+) were 70.00% (7/10) and 68.18% (15/22), respectively. This led to the conclusion that immunization with HBV vaccine before marriage will partly break the HBV transmission chain of "couples-mother and her baby-population".