Matar F A, Mintz G S, Douek P, Farb A, Virmani R, Javier S P, Popma J J, Pichard A D, Kent K M, Satler L F
Cardiac Catheterization Laboratory, Washington Hospital Center, DC.
Cathet Cardiovasc Diagn. 1994 Nov;33(3):214-20. doi: 10.1002/ccd.1810330305.
To validate an automated algorithm for the measurement of lumen volumes of coronary arteries.
Current intravascular ultrasound systems use absolute measurements of and changes in areas and diameters for the assessment of coronary artery disease. However, the coronary artery is a three-dimensional structure of complex geometry and volume.
We used a comprehensive imaging system designed to reconstruct planar intravascular ultrasound images in three dimensions. This system consisted of a 25 MHz transducer-tipped rigid probe (for in vitro studies) or a 25 MHz transducer-tipped catheter within a 3.9F monorail imaging sheath (for in vivo studies), a motorized catheter pullback device that withdrew the transducer at 0.5 mm/sec, and an image processing computer that stacked 15 image slices/mm of vessel axial length and then performed threshold-based three-dimensional image rendering and lumen volume measurement. We imaged 13 human coronary vessels (6 RCA, 6 LAD, 1 LCX) in vitro and 16 vessels (8 LAD, 6 RCA, 2 SVG) in vivo.
Lumen volumes derived by three-dimensional intravascular ultrasound were 171 +/- 121 mm3 and compared very well with those derived by histology (160 +/- 109 mm3, r = 0.97, SEE = 29 mm3, P < 0.001) and with those derived by manual planimetry of planar intravascular ultrasound images (150 +/- 106 mm3, r = 0.97, SEE = 30 mm3, P < 0.001). In vivo studies: Lumen volumes derived by three-dimensional intravascular ultrasound were 74 +/- 35 mm3 and compared well with those derived by quantitative angiography (52 +/- 20 mm3, r = 0.71, SEE = 25 mm3, P < 0.002).
Three-dimensional intravascular ultrasound is a new technique that can accurately measure coronary artery lumen volumes. Further technical improvements may help to establish this technique as the new standard for lumen volume measurement.
验证一种用于测量冠状动脉管腔容积的自动化算法。
当前的血管内超声系统使用面积和直径的绝对测量值及变化来评估冠状动脉疾病。然而，冠状动脉是具有复杂几何形状和容积的三维结构。
我们使用了一个旨在三维重建平面血管内超声图像的综合成像系统。该系统由一个25兆赫换能器尖端的刚性探头（用于体外研究）或一个置于3.9F单轨成像鞘内的25兆赫换能器尖端导管（用于体内研究）、一个以0.5毫米/秒的速度回撤换能器的电动导管回撤装置以及一台图像处理计算机组成，该计算机将每毫米血管轴向长度的15个图像切片堆叠起来，然后进行基于阈值的三维图像渲染和管腔容积测量。我们对13条人体冠状动脉血管进行了体外成像（6条右冠状动脉、6条左前降支、1条左旋支），对16条血管进行了体内成像（8条左前降支、6条右冠状动脉、2条大隐静脉桥血管）。
三维血管内超声得出的管腔容积为171±121立方毫米，与组织学得出的结果（160±109立方毫米，r = 0.97，标准误 = 29立方毫米，P < 0.001）以及平面血管内超声图像手动平面测量得出的结果（150±106立方毫米，r = 0.97，标准误 = 30立方毫米，P < 0.001）相比，吻合度非常好。体内研究：三维血管内超声得出的管腔容积为74±35立方毫米，与定量血管造影得出的结果（52±20立方毫米，r = 0.71，标准误 = 25立方毫米，P < 0.002）相比，吻合度良好。
三维血管内超声是一种能够准确测量冠状动脉管腔容积的新技术。进一步的技术改进可能有助于将该技术确立为管腔容积测量的新标准。
