Bruining N, von Birgelen C, de Feyter P J, Ligthart J, Li W, Serruys P W, Roelandt J R
Thoraxcenter, Department of Cardiology, Erasmus Medical Center and Erasmus University, Rotterdam, The Netherlands.
Cathet Cardiovasc Diagn. 1998 Mar;43(3):254-60. doi: 10.1002/(sici)1097-0304(199803)43:3<254::aid-ccd3>3.0.co;2-8.
The quantitative analysis of a three-dimensional (3-D) intracoronary ultrasound (ICUS) image data set permits a more comprehensive assessment of coronary arterial segments. The 3-D image sets are generally acquired during continuous motorized pullbacks. However, the cyclic changes of vascular dimensions and the cyclic spatial displacement of the ICUS transducer relative to the vessel wall can result in characteristic image artifacts, which may limit the applicability of quantitative automated analysis systems. This limitation may be overcome by an ECG-gated image acquisition. In the present study we acquired in vivo (1) nongated and (2) ECG-gated 3-D ICUS image sets of 15 human atherosclerotic coronary arteries and performed a computer-assisted contour detection of the lumen and total vessel boundaries. Total vessel and lumen volumes measured significantly larger in the nongated versus ECG-gated end-diastolic image sets (753+/-307 mm3 vs. 705+/-305 mm3; 411+/-154 mm3 vs. 388+/-165 mm3, both: P < 0.05). Both end-diastolic and systolic measurements were available in nine arteries, showing a larger total vessel and lumen volume at systole (664+/-221 mm3 vs. 686+/-227 mm3, P=0.03; 384+/-164 mm3 vs. 393+/-170 mm3, P=0.08). The differences observed may be of particular interest for volumetric ICUS studies, addressing presumably small differences in vessel or lumen dimensions.
对三维（3-D）冠状动脉内超声（ICUS）图像数据集进行定量分析，可更全面地评估冠状动脉节段。3-D图像集通常在连续电动回撤过程中获取。然而，血管尺寸的周期性变化以及ICUS换能器相对于血管壁的周期性空间位移可能会导致特征性图像伪影，这可能会限制定量自动分析系统的适用性。通过心电图门控图像采集可以克服这一限制。在本研究中，我们采集了15条人类动脉粥样硬化冠状动脉的体内（1）非门控和（2）心电图门控3-D ICUS图像集，并对管腔和整个血管边界进行了计算机辅助轮廓检测。在非门控与心电图门控舒张末期图像集中，整个血管和管腔体积测量值显著更大（分别为753±307 mm3对705±305 mm3；411±154 mm3对388±165 mm3，均为P<0.05）。九条动脉同时获得了舒张末期和收缩期测量值，结果显示收缩期整个血管和管腔体积更大（分别为664±221 mm3对686±227 mm3，P=0.03；384±164 mm3对393±170 mm3，P=0.08）。观察到的差异可能对容积ICUS研究特别有意义，该研究关注的可能是血管或管腔尺寸的微小差异。
