Bhayana V, Gougoulias T, Cohoe S, Henderson A R
Department of Laboratory Medicine, University Hospital, (University of Western Ontario), London, Ontario, Canada.
Clin Chem. 1995 Feb;41(2):312-7.
Two patients were investigated for unexplained increases in troponin T. In the first patient, who had rhabdomyolysis and acute renal failure, troponin T reached a peak value of 13.50 micrograms/L (67.5-fold the upper reference limit). The second patient had chronic renal failure and the troponin T peak value was 2.85 micrograms/L (14.3-fold the upper reference limit). Clinical investigations indicated no evidence of myocardial damage. Serum or plasma specimens were analyzed for total creatine kinase (CK), CK-2 mass, CK-2 isoform ratio, myoglobin, troponin T, troponin I, and myosin light chains; all except troponin I were at above-normal concentrations. We also investigated six additional renal patients with above-normal troponin T; troponin I was slightly increased in only one of these six patients. Our findings demonstrate discordance between results for troponin T and troponin I in renal patients.
对两名肌钙蛋白T不明原因升高的患者进行了调查。在第一名患有横纹肌溶解症和急性肾衰竭的患者中，肌钙蛋白T达到峰值13.50微克/升（是参考上限的67.5倍）。第二名患者患有慢性肾衰竭，肌钙蛋白T峰值为2.85微克/升（是参考上限的14.3倍）。临床检查未发现心肌损伤的证据。对血清或血浆标本进行了总肌酸激酶（CK）、CK-2质量、CK-2同工酶比率、肌红蛋白、肌钙蛋白T、肌钙蛋白I和肌球蛋白轻链分析；除肌钙蛋白I外，所有指标浓度均高于正常。我们还调查了另外六名肌钙蛋白T高于正常的肾病患者；这六名患者中只有一名肌钙蛋白I略有升高。我们的研究结果表明肾病患者中肌钙蛋白T和肌钙蛋白I的结果不一致。
