Moskow B S, Gold S I, Gottsegen R
J Periodontol. 1976 Oct;47(10):596-606. doi: 10.1902/jop.1976.47.10.596.
Standardized wounds were created in the femurs of 13 female white New Zealand rabbits and implanted with autogenous scleral connective tissue, Achilles bovine tendon collagen chips and cores of cancellous autogenous bone and marrow. A blood-filed wound served as a control. The dynamics of the healing of these wounds over periods of time ranging from 12 days to 3 months was studied by routine histology, fluorescent microscopy and by radiography. Rapid healing of the control and bone implant wounds occurred but was retarded by the implantation of sclera. Collagen chips provoked an active lymphocytic response and severely impeded the healing of the experimental wounds. These experiments were discussed in light of the current interest in allogenic scleral implants in periodontal therapy.
在13只雌性白色新西兰兔的股骨上制造标准化伤口，并植入自体巩膜结缔组织、跟腱牛腱胶原芯片以及自体松质骨和骨髓芯。以充满血液的伤口作为对照。通过常规组织学、荧光显微镜检查和射线照相术研究了这些伤口在12天至3个月时间内的愈合动态。对照伤口和骨植入伤口愈合迅速，但巩膜植入会使其愈合延迟。胶原芯片引发了活跃的淋巴细胞反应，并严重阻碍了实验伤口的愈合。结合当前对同种异体巩膜植入物在牙周治疗中的关注对这些实验进行了讨论。
