伊拉地平对乙醇辨别反应的阻断作用。
Blockade of ethanol discrimination by isradipine.
作者信息
Colombo G, Agabio R, Lobina C, Reali R, Fadda F, Gessa G L
机构信息
Bernard B. Brodie Department of Neuroscience, University of Cagliari, Italy.
出版信息
Eur J Pharmacol. 1994 Nov 24;265(3):167-70. doi: 10.1016/0014-2999(94)90427-8.
The effect of the dihydropyridine Ca2+ channel antagonist, isradipine, on ethanol discrimination was assessed in rats trained to discriminate 1.5 g/kg ethanol from water in a T-maze, food-reinforced drug discrimination procedure. Pretreatment with isradipine (0, 1.0, 3.0 and 5.0 mg/kg i.p.) resulted in a dose-dependent blockade of ethanol discrimination. The results of the present study suggest that L-type Ca2+ channels are involved in the mediation of ethanol discriminative stimulus effects.
在一种食物强化的药物辨别程序中，使用T型迷宫训练大鼠区分1.5克/千克乙醇和水，在此基础上评估二氢吡啶类钙离子通道拮抗剂伊拉地平对乙醇辨别能力的影响。腹腔注射伊拉地平（0、1.0、3.0和5.0毫克/千克）进行预处理，结果显示对乙醇辨别能力的阻断呈剂量依赖性。本研究结果表明，L型钙离子通道参与了乙醇辨别性刺激效应的介导过程。
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