Hofman P, Michiels J F, Mondain V, Saint-Paul M C, Rampal A, Loubière R
Service d'Anatomo-Pathologie, Hôpital Pasteur, Nice.
Gastroenterol Clin Biol. 1994;18(10):895-7.
We report a case of an acute toxoplasmic pancreatitis that led to the death of an AIDS patient. Aetiological diagnosis was performed by the post mortem histological examination. On haematein-eosin staining, toxoplasmic cysts and pseudocysts were noted in the pancreatic acini. Immunohistochemical study using anti-Toxoplasma gondii polyclonal antibodies showed free parasitic forms or tachyzoites in the necrotic areas. Toxoplasmic cysts without any inflammatory reaction were observed in the lungs. In the acquired immunodeficiency syndrome, involvement of the pancreas by toxoplasmosis is very rare and associated with a multivisceral dissemination. Even if this diagnosis is exceptional, acute toxoplasmic pancreatitis must be considered in an AIDS patient when the other causes of pancreatitis, as drugs or infectious diseases, have been eliminated.
我们报告一例急性弓形虫性胰腺炎导致艾滋病患者死亡的病例。病因诊断通过尸检组织学检查进行。苏木精-伊红染色显示,胰腺腺泡中有弓形虫囊肿和假囊肿。使用抗刚地弓形虫多克隆抗体进行的免疫组织化学研究显示,坏死区域有游离的寄生虫形式或速殖子。肺部观察到无任何炎症反应的弓形虫囊肿。在获得性免疫缺陷综合征中,胰腺受弓形虫感染非常罕见,且与多脏器播散有关。即使这种诊断很罕见,但当排除了胰腺炎的其他病因,如药物或传染病等,艾滋病患者出现急性胰腺炎时,必须考虑急性弓形虫性胰腺炎的可能。