大鼠苯丙氨酸羟化酶编码基因的紧邻5'侧翼区域。
The immediate 5'-flanking region of the rat phenylalanine hydroxylase-encoding gene.
作者信息
McDowall I L, Fisher M J
机构信息
Department of Biochemistry, University of Liverpool, UK.
出版信息
Gene. 1995 Feb 14;153(2):289-90. doi: 10.1016/0378-1119(94)00802-y.
We have characterized the immediate (465 bp) 5'-flanking region of the rat phenylalanine hydroxylase (PAH)-encoding gene. This sequence shows considerable similarity to the 5'-flanking region of the human PAH gene [Konecki et al., Biochemistry 31 (1992) 8363-8368]. Both sequences lack obvious TATA elements; however, putative regulatory sites, including a potential cyclic AMP-response element and glucocorticoid response elements, are present.
我们已经对大鼠苯丙氨酸羟化酶（PAH）编码基因紧邻的（465碱基对）5'侧翼区域进行了特征分析。该序列与人类PAH基因的5'侧翼区域显示出相当大的相似性[科内茨基等人，《生物化学》31（1992）8363 - 8368]。两个序列都缺乏明显的TATA元件；然而，存在包括潜在的环磷酸腺苷反应元件和糖皮质激素反应元件在内的假定调控位点。
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