Roos M T, Miedema F, Koot M, Tersmette M, Schaasberg W P, Coutinho R A, Schellekens P T
Department of Clinical Viro-Immunology, Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Amsterdam.
J Infect Dis. 1995 Mar;171(3):531-6. doi: 10.1093/infdis/171.3.531.
The predictive value of low T cell reactivity to CD3 monoclonal antibodies for development of AIDS was evaluated and compared with low CD4+ cell numbers and the presence of syncytium-inducing human immunodeficiency virus (HIV) variants in 122 seropositive asymptomatic homosexual men for 4.5 years. Low T cell reactivity was a strong predictor for progression to AIDS in a multivariate proportional hazards analysis using these markers as covariates at entry and as time-dependent covariates. The combination of the three markers was associated with development of AIDS in 6 of 7 men within 15 months. In contrast, the group that lacked any of these markers had a very low risk (11%) for developing AIDS. In groups with one or two of these three markers, progression rates were 33% and 66%, respectively. These data demonstrate that measurement of T cell function in vitro is of value for staging of HIV infection and may be useful for monitoring therapy.
在122名血清反应阳性的无症状同性恋男性中，对其针对CD3单克隆抗体的低T细胞反应性在艾滋病发展中的预测价值进行了评估，并与低CD4 +细胞数量以及合胞体诱导型人类免疫缺陷病毒（HIV）变体的存在情况进行了4.5年的比较。在多变量比例风险分析中，将这些标志物作为进入时的协变量以及随时间变化的协变量，低T细胞反应性是进展为艾滋病的有力预测指标。在15个月内，这三种标志物组合在7名男性中有6名与艾滋病的发展相关。相比之下，缺乏这些标志物中任何一种的组发生艾滋病的风险非常低（11%）。在具有这三种标志物中的一种或两种的组中，进展率分别为33%和66%。这些数据表明，体外测量T细胞功能对HIV感染分期有价值，可能对监测治疗也有用。
