Schmader K, George L K, Burchett B M, Pieper C F, Hamilton J D
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710.
J Infect Dis. 1995 Mar;171(3):701-4. doi: 10.1093/infdis/171.3.701.
The purpose of this study was to determine if there are racial differences in the occurrence of herpes zoster (shingles). The study population was the Duke Established Populations for Epidemiologic Studies of the Elderly, a probability sample of community-dwelling persons > 64 years old in North Carolina. Interviewers administered a comprehensive health survey to the participants that included questions about lifetime occurrence of shingles. Of the 3206 subjects, 316 (9.9%) had had zoster: 81 (4.5%) of 1754 blacks and 235 (16.1%) of 1452 whites had had shingles (P < .0001). After controlling for age, cancer, and demographic factors, blacks remained one-fourth as likely as whites (adjusted odds ratio 0.25, 95% confidence interval 0.18-0.35; P = .0001) to have experienced zoster. In summary, blacks had a significantly lower risk of developing herpes zoster than whites, a new finding in herpes zoster epidemiology.
本研究的目的是确定带状疱疹（俗称“缠腰龙”）的发病是否存在种族差异。研究对象是杜克老年流行病学研究既定人群，这是北卡罗来纳州64岁以上社区居住者的概率样本。访员对参与者进行了全面的健康调查，其中包括有关带状疱疹终生发病情况的问题。在3206名受试者中，316人（9.9%）曾患带状疱疹：1754名黑人中有81人（4.5%），1452名白人中有235人（16.1%）曾患带状疱疹（P<0.0001）。在控制年龄、癌症和人口统计学因素后，黑人患带状疱疹的可能性仍仅为白人的四分之一（调整后的优势比为0.25，95%置信区间为0.18 - 0.35；P = 0.0001）。总之，黑人患带状疱疹的风险显著低于白人，这是带状疱疹流行病学中的一项新发现。
