Schmader K, George L K, Burchett B M, Pieper C F
Department of Psychiatry and Sociology, Duke University Medical Center, Durham, NC 27710, USA.
J Infect Dis. 1998 Nov;178 Suppl 1:S67-70. doi: 10.1086/514254.
The effects of black race and psychologic stress on the risk of acquiring herpes zoster in late life were examined. Subjects were participants of a stratified probability sample of community-dwelling persons > or = 65 years old. A comprehensive health survey was administered in 1986-1987 (P1), 1989-1990 (P2), and 1992-1994 (P3). Incident cases of zoster between P1 and P2 and P2 and P3 served as the dependent variables. Hypothesis-testing variables included race, negative life events, and measures of social support. Control variables included age, sex, education, cancer, other chronic diseases, hospitalization, activities of daily living, self-rated health, depression, and cigarette smoking. From P1 to P2, 1.4% of black and 3.4% of white subjects developed zoster (P < .001). From P2 to P3, 2.9% of black and 7.5% of white subjects developed zoster (P < .001). After controlling for variables, black subjects were significantly less likely to develop zoster than were white subjects (adjusted odds ratio, 0.37; 95% confidence interval, 0.26, 0.53; P = .0001). Most measures of stress were not significantly related to zoster; however, study limitations preclude definitive conclusions.
研究了黑人种族和心理压力对老年人患带状疱疹风险的影响。研究对象是年龄≥65岁的社区居住者分层概率样本中的参与者。在1986 - 1987年（P1）、1989 - 1990年（P2）和1992 - 1994年（P3）进行了全面的健康调查。P1与P2之间以及P2与P3之间带状疱疹的发病病例作为因变量。假设检验变量包括种族、负面生活事件和社会支持指标。控制变量包括年龄、性别、教育程度、癌症、其他慢性病、住院情况、日常生活活动、自评健康状况、抑郁和吸烟情况。从P1到P2，1.4%的黑人受试者和3.4%的白人受试者患带状疱疹（P < .001）。从P2到P3，2.9%的黑人受试者和7.5%的白人受试者患带状疱疹（P < .001）。在对变量进行控制后，黑人受试者患带状疱疹的可能性显著低于白人受试者（调整后的优势比为0.37；95%置信区间为0.26, 0.53；P = .0001）。大多数压力指标与带状疱疹无显著相关性；然而，研究的局限性排除了得出确定性结论的可能性。
