Miró O, Moreno A, Valls M E, Miró J M, Piqué J M, Bordas J M, Moreno-Martínez A, Bombí J A, Gatell J M
Servicio de Enfermedades Infecciosas, Hospital Clínic i Provincial, Facultad de Medicina, Universidad de Barcelona.
Med Clin (Barc). 1995 Jan 28;104(3):96-9.
Enterocytozoon bieneusi is a protozoa belonging to the Microsporidia family which prevalence has increased in AIDS patients. Although diagnosis is performed by the demonstration of the parasite in the epithelium of the small intestine by light and electron microscopy, techniques allowing diagnosis from stools or duodenal or biliary aspirates have recently been described. Three cases of intestinal microsporidiosis diagnosed by the mentioned method are reported. The patients were 3 males with chronic diarrhea of several months of evolution with an important ponderal loss. All were in advanced stages of HIV infection with CD4-lymphocyte counts lower than 0.1 x 10(9)/l. In all the patients in whom intestinal absorption tests were performed these were found to be altered. One of the patients presented concommitant cholestasis with parasitation by E. bieneusi being demonstrated as by the biliary route in this patient. Confirmation of infection by E. bieneusi was performed in the 3 cases by electron microscopy study of stools. A review of intestinal microsporidiosis in AIDS patients is carried out and the therapeutic possibilities available for this infection are discussed.
肠微孢子虫是一种属于微孢子虫科的原生动物，在艾滋病患者中的感染率有所上升。尽管通过光学显微镜和电子显微镜在小肠上皮中发现寄生虫来进行诊断，但最近已描述了可从粪便、十二指肠或胆汁抽吸物中进行诊断的技术。本文报告了3例通过上述方法诊断的肠道微孢子虫病病例。患者为3名男性，患有长达数月的慢性腹泻，并伴有严重体重减轻。所有患者均处于HIV感染晚期，CD4淋巴细胞计数低于0.1×10⁹/L。在所有进行肠道吸收试验的患者中，均发现试验结果异常。其中一名患者同时出现胆汁淤积，通过该患者的胆汁途径证实存在肠微孢子虫寄生。通过对粪便进行电子显微镜研究，对这3例病例均确诊为肠微孢子虫感染。本文对艾滋病患者的肠道微孢子虫病进行了综述，并讨论了针对这种感染的治疗可能性。
