Frenkel Y, Kopernik G, Lazer S, Tugendreich D, Zmira N, Oettinger M, Tendler R, Serr D M
Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Sackler Shool of Medicine, Tel Aviv University, Tel Hashomer, Israel.
Maturitas. 1994 Nov;20(1):31-6. doi: 10.1016/0378-5122(94)90098-1.
The acceptability and skin reaction of Estraderm Transdermal Therapeutic Systems as a function of climatic variability were examined in various zones which alter considerably in their temperature and humidity. An open, noncomparative prospective study was carried out in four institutional out-patient menopausal clinics in varying climatic areas. Eighty symptomatic postmenopausal patients without previous estrogen replacement were examined. Estraderm T.T.S. 50 was applied twice weekly in four weekly cycles. Norethisterone-acetate tablets (1 mg), were taken orally for 12 consecutive days. Using a questionnaire, the subjects were asked about the efficacy of the treatment on postmenopausal symptoms, the adhesiveness and tolerability. The results were matched with the meteorological conditions. The duration of the study was 6 months. Acceptability of Estraderm T.T.S. is high (78.7%). Discontinuation of treatment was found in 21.3% of the study group. The main reason for discontinuation is due to skin reactions which occurred in 14 of the 80 patients (17.5%). Meteorological conditions in this study did not influence the rate of skin reactions. No difference in acceptability of the treatment was found in relation to the mean temperature and mean humidity as registered in the dry desert and the humid coastal areas.
在温度和湿度变化显著的不同区域，研究了雌二醇透皮治疗系统的可接受性及皮肤反应与气候变异性之间的关系。在气候各异的四个机构性门诊绝经诊所开展了一项开放性、非对照前瞻性研究。对80名有症状的绝经后患者进行了检查，这些患者此前未接受过雌激素替代治疗。雌二醇透皮治疗系统50每周应用两次，共四个周期。连续12天口服醋酸炔诺酮片（1毫克）。通过问卷调查，询问受试者关于治疗对绝经后症状的疗效、黏附性和耐受性。将结果与气象条件进行匹配。研究持续时间为6个月。雌二醇透皮治疗系统的可接受性较高（78.7%）。研究组中有21.3%的患者停止治疗。停止治疗的主要原因是皮肤反应，80名患者中有14名出现皮肤反应（17.5%）。本研究中的气象条件并未影响皮肤反应发生率。在干燥沙漠地区和潮湿沿海地区记录的平均温度和平均湿度方面，未发现治疗可接受性存在差异。
