Chin H
Third Department of Surgery, Tokyo University School of Medicine, Japan.
Nihon Geka Gakkai Zasshi. 1994 Dec;95(12):866-74.
I report the detailed morphological changes of the endocrine pancreas after gastrectomy, by PAP stain method, using gastrectomized rats. Regarding the number-ratio and the occupied area-ratio of the B and A cells in each Langerhans islet, there was no difference in each group. But regarding the D cell in totally gastrectomized rats, especially in EJ group (total gastrectomy, esophagojejunostomy with Braun anastomosis), the most notable morphological changes were recognized, namely the occupied area-ratio and the number-ratio of the D cell in each Langerhans islet increased to 3.57 +/- 1.64% and 11.73 +/- 3.89%. In gastrectomized rats, the structure of the B and A cells in each Langerhans islet was comparatively well-preserved. In totally gastrectomized rats, especially in EJ group, the more remarkable increase of the D cell in each Langerhans islet was recognized. It is though that because of the loss of the stomach, the secretory changes of the gut hormones and the accelerated intestinal transit and etc., the D cell increased compensatorily.
我通过PAP染色法，利用胃切除大鼠报告胃切除术后内分泌胰腺的详细形态学变化。关于每个胰岛中B细胞和A细胞的数量比及所占面积比，各实验组间无差异。但对于全胃切除大鼠，尤其是EJ组（全胃切除、食管空肠吻合术加布朗吻合术），D细胞出现了最显著的形态学变化，即每个胰岛中D细胞的所占面积比及数量比分别增加至3.57±1.64%和11.73±3.89%。在胃切除大鼠中，每个胰岛中B细胞和A细胞的结构保存相对完好。在全胃切除大鼠中，尤其是EJ组，每个胰岛中D细胞的增加更为显著。推测是由于胃的缺失、肠道激素分泌变化以及肠道转运加快等原因，D细胞出现了代偿性增加。
