ppGpp对RNA聚合酶特异性的调控
Modulation of RNA polymerase specificity by ppGpp.
作者信息
Travers A
出版信息
Mol Gen Genet. 1976 Aug 19;147(2):225-32. doi: 10.1007/BF00267575.
PMID:787760
Abstract
ppGpp alters the initiation specificity of RNA polymerase holoenzyme in vitro in a direction which mimics the stringent response in vivo. The transition temperature for opening rRNA promoters is increased by the nucleotide, that for opening phi80 promoters is unaffected. This implies that RNA polymerase can discriminate between different types of promoter. ppGpp may act by effecting a structural change in the enzyme.
摘要
鸟苷四磷酸（ppGpp）在体外改变了RNA聚合酶全酶的起始特异性，其改变方向模拟了体内的严谨反应。该核苷酸增加了核糖体RNA（rRNA）启动子开放的转变温度，而对φ80启动子开放的转变温度没有影响。这意味着RNA聚合酶能够区分不同类型的启动子。ppGpp可能通过影响酶的结构变化而起作用。
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