Rajakumar D V, Rao M N
Department of Pharmaceutical Chemistry, College of Pharmaceutical Sciences, Manipal, India.
Mol Cell Biochem. 1994 Nov 9;140(1):73-9. doi: 10.1007/BF00928368.
The present study investigates the inhibition of lipid peroxidation by dehydrozingerone and curcumin in rat brain homogenates. Both the test compounds inhibited the formation of conjugated dienes and spontaneous lipid peroxidation. These compounds also inhibited lipid peroxidation induced by ferrous ions, ferric-ascorbate and ferric-ADP-ascorbate. In all these cases, curcumin was more active than dehydrozingerone and dl-alpha-tocopherol.
本研究调查了脱氢姜酮和姜黄素对大鼠脑匀浆脂质过氧化的抑制作用。两种受试化合物均抑制共轭二烯的形成和自发性脂质过氧化。这些化合物还抑制了由亚铁离子、抗坏血酸铁和抗坏血酸铁 - ADP诱导的脂质过氧化。在所有这些情况下，姜黄素比脱氢姜酮和dl-α-生育酚更具活性。
