[消旋]-α-生育酚对氯化亚铁诱导的大鼠杏仁核脂质过氧化的影响。

Effect of [dl]-alpha-tocopherol on FeCl2-induced lipid peroxidation in rat amygdala.

作者信息

Triggs W J, Willmore L J

机构信息

Department of Neurology, University of Florida College of Medicine, Gainesville.

出版信息

Neurosci Lett. 1994 Oct 10;180(1):33-6. doi: 10.1016/0304-3940(94)90907-5.

DOI:10.1016/0304-3940(94)90907-5

PMID:7877756

Abstract

Peroxidative injury of neural membrane lipids can be initiated by iron-containing blood products, chelated ferrous or ferric ions, and low valence iron in aqueous solution. Lipid peroxidation was measured following focal injection of 3 microliters of 100 mM FeCl2 into rat amygdala. Acute parenteral administration of [dl]-alpha-tocopherol as the alcohol limited the quantity of peroxidation products generated. These data suggest a potential role for alpha-tocopherol administration in limiting brain injury responses.

摘要

含铁血制品、螯合亚铁或铁离子以及水溶液中的低价铁可引发神经膜脂质的过氧化损伤。在向大鼠杏仁核局部注射3微升100 mM氯化亚铁后测定脂质过氧化。以醇形式急性胃肠外给予[dl]-α-生育酚可限制过氧化产物的生成量。这些数据表明给予α-生育酚在限制脑损伤反应方面具有潜在作用。