Chang S W, Hu F R
Department of Ophthalmology, National Taiwan University Hospital, Taipei, ROC.
Ophthalmic Res. 1994;26(5):283-9. doi: 10.1159/000267490.
We conducted a corneal epithelial permeability study using a fluorophotometer on 93 eyes of 79 patients with clear corneal grafts. There were 45 males and 34 females, aged 61.6 +/- 10.2 years. All eyes received penetrating keratoplasty at least 1 year (mean 40.4 +/- 31.3 months) before examination. The normal fellow eyes of 65 subjects were examined as controls. The averaged corneal epithelial permeability of grafted corneas was significantly higher than that of controls (p < 0.001). In the 65 individuals having an otherwise healthy fellow eye, the grafted corneas were significantly more permeable than their control fellow eyes verified by paired t test (n = 65, p = 0.006). Concomitant corneal sensitivity test revealed a significantly hypesthetic cornea. These results show that in spite of a clinically normal clear graft, there is usually a subnormal epithelial barrier function and reinnervation, even years after corneal transplantation.
我们使用荧光光度计对79例接受透明角膜移植术患者的93只眼进行了角膜上皮通透性研究。其中男性45例，女性34例，年龄61.6±10.2岁。所有患眼在检查前至少1年（平均40.4±31.3个月）接受了穿透性角膜移植术。将65名受试者的健侧眼作为对照进行检查。移植角膜的平均角膜上皮通透性显著高于对照组（p<0.001）。在65名健侧眼健康的个体中，通过配对t检验证实移植角膜的通透性明显高于其健侧对照眼（n = 65，p = 0.006）。同时进行的角膜敏感性测试显示角膜感觉明显减退。这些结果表明，尽管临床上移植角膜外观正常，但即使在角膜移植多年后，通常仍存在上皮屏障功能和神经再支配功能异常。
