Boot J P, van Best J A, Stolwijk T R, Sterk C C
Department of Ophthalmology, University Hospital, Leiden, The Netherlands.
Graefes Arch Clin Exp Ophthalmol. 1991;229(6):533-5. doi: 10.1007/BF00203316.
The epithelial permeability to fluorescein of 27 clear corneal grafts in 23 patients was determined by fluorophotometry at greater than 1 year after penetrating keratoplasty (PKP) so as to study the recovery of corneal epithelial function. The mean epithelial permeability of the corneal grafts did not differ significantly from that of normal corneas (0.042 +/- 0.016 and 0.038 +/- 0.017 nm/s, respectively; P greater than 0.3). Multiple linear regression analysis showed that permeability correlated with recipient age but not with donor age (permeability increase, 0.00054 nm/s per year; r = 0.6, P less than 0.005 and r = 0.1, P greater than 0.5, respectively). These results indicate that corneal grafts can regain a normal epithelial barrier function and that recovery of epithelial function is better in young than in old recipients.
为研究穿透性角膜移植术（PKP）术后1年以上23例患者27只透明角膜移植片的上皮对荧光素的通透性，采用荧光光度法进行测定，以评估角膜上皮功能的恢复情况。角膜移植片的平均上皮通透性与正常角膜相比无显著差异（分别为0.042±0.016和0.038±0.017 nm/s；P＞0.3）。多元线性回归分析显示，通透性与受者年龄相关，而与供者年龄无关（通透性增加，每年0.00054 nm/s；r = 0.6，P＜0.005；r = 0.1，P＞0.5）。这些结果表明，角膜移植片可恢复正常的上皮屏障功能，且年轻受者的上皮功能恢复优于老年受者。
