Borghi F, Petrino R, Bellora P, Gattuso G, Di Napoli A, Cellino G, Levi A C
Istituto di Patologia Chirurgica, Cattedra di Medicina Interna, Ospedale S. Vito, Turin, Italy.
Panminerva Med. 1994 Sep;36(3):149-51.
The existence of the so called "Villus Size Gradient" (VSG) which defines the proportional decrease in height of intestinal villi from duodenum to ileum is well documented in adult animals and man. The aim of this study is to define whether the VSG is present since birth or, if not, when and why it appears. We have measured the height of intestinal villi in 25 rats: 5 at 1 day from birth, 5 at 5 days, 5 at 8 days, 5 at 15 days and 5 at 30 days. We have prepared histological slides of a duodenal, jejunal and ileal tract of each animal and measured the height of villi on microphotographs. At day 1 we observed a higher size of duodenal villi statistically significant with respect to jejunum and ileum, while at day 5 no differences were observed between the various intestinal tracts. The VSG become evident 8 days after birth progressively increasing to day 30. The predominance of duodenum present at birth is therefore probably due to the fetal developmental growth which is known to be more precocious in duodenum than in more distal tracts. Five days after birth the intestinal villi are equally developed, while in later ages the VSG appears. So we can conclude that the VSG is a consequence of luminal and humoral factors and not a predetermined event.
所谓的“绒毛大小梯度”（VSG）定义了从十二指肠到回肠肠绒毛高度的成比例降低，这在成年动物和人类中已有充分记录。本研究的目的是确定VSG在出生时是否存在，如果不存在，它何时出现以及为何出现。我们测量了25只大鼠的肠绒毛高度：出生1天的5只，5天的5只，8天的5只，15天的5只和30天的5只。我们为每只动物的十二指肠、空肠和回肠制备了组织学切片，并在显微照片上测量了绒毛高度。在第1天，我们观察到十二指肠绒毛的大小在统计学上显著高于空肠和回肠，而在第5天，各肠道之间未观察到差异。VSG在出生后8天变得明显，并逐渐增加到第30天。因此，出生时十二指肠的优势可能归因于胎儿发育生长，已知十二指肠的发育比更远端的肠道更早成熟。出生后5天，肠绒毛发育程度相同，而在后期VSG出现。所以我们可以得出结论，VSG是腔内和体液因素的结果，而不是一个预先确定的事件。
