Latgé J P, Paris S, Sarfati J, Debeaupuis J P, Diaquin M, Girardin H
Unité de Mycologie, Institut Pasteur, Paris, France.
Pathol Biol (Paris). 1994 Sep;42(7):632-9.
Development of A. fumigatus in the host tissues is due to the intrinsic biological characteristics of this fungus and to the impairment of the cellular defence reactions of the host. However, even today the understanding of the factors governing the infectivity of A. fumigatus remains very limited. For example, the cellular mechanisms involved in the killing of A. fumigatus are still not elucidated. The cellular site(s) of infection and the role of the different lung epithelia in the establishment of the fungus are unknown. No specific fungal virulence factors have been identified until now. Molecular biology techniques are powerful tools to investigate the pathogenesis of invasive aspergillosis. Recent developments in the study of this mycosis are presented in this review.
烟曲霉在宿主组织中的生长归因于该真菌的内在生物学特性以及宿主细胞防御反应的受损。然而，即便在今天，对控制烟曲霉感染性的因素的理解仍然非常有限。例如，参与杀灭烟曲霉的细胞机制仍未阐明。感染的细胞位点以及不同肺上皮细胞在真菌定植中的作用尚不清楚。迄今为止，尚未鉴定出特定的真菌毒力因子。分子生物学技术是研究侵袭性曲霉病发病机制的有力工具。本文综述了该真菌病研究的最新进展。
