Infectious Diseases Unit, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
Br J Haematol. 2010 Aug;150(4):406-17. doi: 10.1111/j.1365-2141.2010.08283.x. Epub 2010 Jul 7.
Aspergillus fumigatus is an opportunistic filamentous fungus that is currently the most frequent cause of invasive fungal disease in immunosuppressed individuals. Recent advances in our understanding of the pathogenesis of invasive aspergillosis have highlighted the multifactorial nature of A. fumigatus virulence and the complex interplay between host and microbial factors. In this review, we outline current concepts of immune recognition and evasion, angioinvasion and angiogenesis, secondary metabolism and the fungal stress response, and their respective roles in this often lethal infection.
烟曲霉是一种机会性丝状真菌，目前是免疫抑制个体中侵袭性真菌感染的最常见原因。我们对侵袭性曲霉病发病机制的理解的最新进展强调了烟曲霉毒力的多因素性质以及宿主和微生物因素之间的复杂相互作用。在这篇综述中，我们概述了免疫识别和逃逸、血管侵袭和血管生成、次级代谢和真菌应激反应及其在这种经常致命的感染中的各自作用的当前概念。
