Mazars G, Merienne L, Cioloca C
Neurochirurgie. 1976 Jun;22 suppl 1:5-164.
This report presented to the Société de Neurochirurgie de Langue Française is based on 34 years of unique practice in neurosurgical management of pain; during that long period the author and his associates have collected an unusually large experience in almost every field of neurosurgical management of pain; they have improved or fully devised several new techniques which allow them to ground an appreciation of the procedures still worthy to be used in various pain syndromes. The first part of the report deals with "Cybernetics of pain". This rather long chapter is based both on classical data and personal observations on man during and following operations, meant to relieve pain. Though supporting HEAD and HOLMES, theory on Control of protopathic by epicritic Stimuli, the authors consider that the type of pain associated with noxious stimulation as representative of just one among other types of pain, not induced by nociception and not associated with protection reflexes. Sensory deafferentation as can be produced by amputations, herpes zoster, dorsal column or medullary lesions, cannot be included in Sherrington's scheme of psychical mechanisms associated with protection reflexes and yet is responsible for most of the chronic unbearable and often intractable pain. Moreover, an important modulation of pain as such depends on conditioning, on inherited and acquired patterns of behaviour and on a multiplicating factor which is provisionally named "algogenic neurosis". The fact that an intact nucleus ventralis posterolateralis is a necessity for a "no pain status" tends to prove that this thalamic nucleus acts as a major inhibiting relay on the pain integrating system and for several additional reasons is the level of integration of epicritic versus protopathic stimuli in case of true nociception...
这份提交给法国神经外科学会的报告基于34年来在疼痛神经外科治疗方面的独特实践;在那段漫长的时期里,作者及其同事在疼痛神经外科治疗的几乎每个领域都积累了异常丰富的经验;他们改进或完全设计了几种新技术,这使他们能够对仍值得在各种疼痛综合征中使用的手术方法进行评估。报告的第一部分涉及“疼痛控制论”。这一相当长的章节既基于经典数据,也基于作者在手术期间及术后对人类的个人观察,这些观察旨在缓解疼痛。尽管支持海德和霍姆斯关于精细感觉刺激控制原始感觉的理论,但作者认为,与有害刺激相关的疼痛类型只是其他类型疼痛中的一种,并非由伤害性感受引起,也与保护反射无关。截肢、带状疱疹、背柱或延髓病变所导致的感觉传入神经阻滞,不能被纳入谢灵顿与保护反射相关的心理机制范畴,但却导致了大多数慢性的、难以忍受且往往难以治疗的疼痛。此外,疼痛本身的一个重要调节取决于条件作用、遗传和后天习得的行为模式以及一个暂时命名为“致痛神经症”的倍增因素。完整的丘脑后外侧腹核是“无痛状态”的必要条件,这一事实倾向于证明,这个丘脑核在疼痛整合系统中起着主要抑制中继的作用,并且由于其他几个原因,在真正的伤害性感受情况下,它是精细感觉与原始感觉刺激的整合水平……