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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Clin Exp Pharmacol Physiol. 1978 May-Jun;5(3):223-7. doi: 10.1111/j.1440-1681.1978.tb00675.x.

Iopanoic acid and iophenoxic acid were potent inhibitors of compound 48/80-induced histamine release from rat peritoneal cell suspensions rich in mast cells and caused a parallel dose-related reduction in ATP content of these cells. 2. Lignocaine was less potent and ouabain and probenecid were ineffective in inhibiting histamine release and reducing cellular ATP content. 3. Various drugs can inhibit 48/80-induced histamine release from rat peritoneal cells and this activity may result from depletion of cellular ATP. It is apparent that little structural specificity is required for activity in this cell system.

碘番酸和碘苯氧酸是化合物48/80诱导富含肥大细胞的大鼠腹腔细胞悬液释放组胺的强效抑制剂，并使这些细胞的ATP含量呈平行的剂量相关性降低。2. 利多卡因的效力较弱，而哇巴因和丙磺舒在抑制组胺释放和降低细胞ATP含量方面无效。3. 多种药物可抑制化合物48/80诱导的大鼠腹腔细胞组胺释放，这种活性可能源于细胞ATP的耗竭。显然，在这个细胞系统中发挥活性所需的结构特异性很小。

Clin Exp Pharmacol Physiol. 1978 May-Jun;5(3):223-7. doi: 10.1111/j.1440-1681.1978.tb00675.x.

Iopanoic acid and iophenoxic acid were potent inhibitors of compound 48/80-induced histamine release from rat peritoneal cell suspensions rich in mast cells and caused a parallel dose-related reduction in ATP content of these cells. 2. Lignocaine was less potent and ouabain and probenecid were ineffective in inhibiting histamine release and reducing cellular ATP content. 3. Various drugs can inhibit 48/80-induced histamine release from rat peritoneal cells and this activity may result from depletion of cellular ATP. It is apparent that little structural specificity is required for activity in this cell system.

碘番酸和碘苯氧酸是化合物48/80诱导富含肥大细胞的大鼠腹腔细胞悬液释放组胺的强效抑制剂，并使这些细胞的ATP含量呈平行的剂量相关性降低。2. 利多卡因的效力较弱，而哇巴因和丙磺舒在抑制组胺释放和降低细胞ATP含量方面无效。3. 多种药物可抑制化合物48/80诱导的大鼠腹腔细胞组胺释放，这种活性可能源于细胞ATP的耗竭。显然，在这个细胞系统中发挥活性所需的结构特异性很小。