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[Colchicine poisoning apropos of a pediatric case].

作者信息

Dubois V, Rey N, Constant H, Scherrmann J M, Berthier J C, Aulagner G

机构信息

Service de Pharmacie, Hôpital Debrousse, Lyon.

出版信息

Therapie. 1994 Jul-Aug;49(4):339-42.

PMID:7878601
Abstract

Colchicine has been widely used in the treatment of gout and familial mediterranean fever. Overdose is rare mostly in childhood. Colchicine overdose always causes gastrointestinal side effects, bone marrow depression and sometimes neuropathy. The mechanism of colchicine upon the microtubules, provides a better understanding of the pharmacology and also of the multiorgan involvement. We report the case of a ten year old child who ingested 0.6 mg/kg colchicine with a good outcome.

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