Dubois V, Rey N, Constant H, Scherrmann J M, Berthier J C, Aulagner G
Service de Pharmacie, Hôpital Debrousse, Lyon.
Therapie. 1994 Jul-Aug;49(4):339-42.
Colchicine has been widely used in the treatment of gout and familial mediterranean fever. Overdose is rare mostly in childhood. Colchicine overdose always causes gastrointestinal side effects, bone marrow depression and sometimes neuropathy. The mechanism of colchicine upon the microtubules, provides a better understanding of the pharmacology and also of the multiorgan involvement. We report the case of a ten year old child who ingested 0.6 mg/kg colchicine with a good outcome.
秋水仙碱已被广泛用于治疗痛风和家族性地中海热。过量服用在儿童中较为罕见。秋水仙碱过量服用总会导致胃肠道副作用、骨髓抑制，有时还会引起神经病变。秋水仙碱作用于微管的机制，有助于更好地理解其药理学以及多器官受累情况。我们报告一例10岁儿童摄入0.6mg/kg秋水仙碱但预后良好的病例。
