Gubskiĭ Iu I, Litvinova N V, Shnurko-Tabakova E V
Ukr Biokhim Zh (1978). 1994 Jul-Aug;66(4):114-7.
Antiradical and antioxidative activities of classic phenolic antioxidants and blockers of Ca(2+)-channel have been studied. K2 rate constants and pI50 concentrations of tested physiologically active substances have been determined. Using the model systems of hepatic microsomal membranes lipoperoxidation it is shown that there is no distinct correlation between the antiradical and antioxidative activities of substances under investigation. These results have shown a necessity of complex evaluation of antioxidant properties of pharmacological drugs.
对经典酚类抗氧化剂和钙通道阻滞剂的抗自由基和抗氧化活性进行了研究。已测定受试生理活性物质的二级反应速率常数（K2）和半数抑制浓度（pI50）。利用肝微粒体膜脂质过氧化的模型系统表明，所研究物质的抗自由基和抗氧化活性之间没有明显的相关性。这些结果表明有必要对药物的抗氧化特性进行综合评估。
