Koney E B, Morrow A N, Heron I, Ambrose N C, Scott G R
Veterinary Services Department, Ministry of Agriculture, Accra, Ghana.
Vet Parasitol. 1994 Nov;55(3):245-56. doi: 10.1016/0304-4017(94)00648-V.
The proliferative response of lymphocytes from tick-infested Zebu type, N'Dama and Friesian cattle and acaricide-treated Zebu types and Friesians in concanavalin A (Con A) stimulated cultures was monitored regularly for periods ranging from 11 to 27 months. The numbers of ticks on the animals and the presence of dermatophilosis were also noted. The Friesian cattle carried most and the N'Dama fewest Amblyomma variegatum ticks. The tick-infested Friesians all developed severe clinical dermatophilosis within 5 months of becoming tick-infested. Dermatophilosis lesions on the tick-infested Zebu type and N'Dama cattle were less common and less severe especially in the N'Damas. The proliferative response of lymphocytes from tick-infested Friesians in Con A stimulated cultures fell to almost half that of the acaricide-treated Friesians soon after the former became tick-infested. The tick-infested Zebu types also developed a depressed response compared with the tick-free Zebu group over a 27 month study period. However, the responses of the N'Damas was similar to that of the tick-free Zebu types. The addition of autologous serum to Con A stimulated cultures of lymphocytes derived from the tick-infested Zebu types and N'Damas suppressed their proliferative response compared with that of similar cultures for the tick-free Zebu types.
对来自受蜱虫侵扰的瘤牛型、恩达马牛和弗里西亚牛以及经杀螨剂处理的瘤牛型和弗里西亚牛的淋巴细胞，在刀豆蛋白A（Con A）刺激培养物中的增殖反应进行了为期11至27个月的定期监测。还记录了动物身上蜱虫的数量以及皮肤嗜皮菌病的存在情况。弗里西亚牛身上携带的杂色斑蜱最多，恩达马牛身上最少。受蜱虫侵扰的弗里西亚牛在受蜱虫侵扰后的5个月内均出现了严重的临床皮肤嗜皮菌病。受蜱虫侵扰的瘤牛型和恩达马牛身上的皮肤嗜皮菌病病变较少见且不太严重，尤其是在恩达马牛中。受蜱虫侵扰的弗里西亚牛的淋巴细胞在Con A刺激培养物中的增殖反应在受蜱虫侵扰后不久就降至经杀螨剂处理的弗里西亚牛的近一半。在为期27个月的研究期内，受蜱虫侵扰的瘤牛型与无蜱虫的瘤牛组相比，其反应也出现了下降。然而，恩达马牛的反应与无蜱虫的瘤牛型相似。与无蜱虫的瘤牛型的类似培养物相比，向来自受蜱虫侵扰的瘤牛型和恩达马牛的淋巴细胞的Con A刺激培养物中添加自体血清会抑制它们的增殖反应。
