Steck T, Würfel W
Universitäts-Frauenklinik Würzburg.
Zentralbl Gynakol. 1995;117(1):3-10.
Pregnancy-induced hypertension (PIH) is a placental disease that mainly occurs in primigravidae, but its precise etiology is not yet known. It has long been considered that the protective effect of multiparity may be due to immunological factors. Here, we review epidemiologic data from the literature supporting the idea of a possible immunological basis of PIH. There are conflicting reports in the literature regarding the involvement of cellular and humoral mechanisms in the etiology of PIH, the impact of histocompatibility and the interactions between maternal and fetal genotype. Finally, the evidence for a common immunologic cause for pregnancy-induced hypertension and miscarriage is discussed.
妊娠高血压综合征（PIH）是一种主要发生于初产妇的胎盘疾病，但其确切病因尚不清楚。长期以来，人们一直认为经产妇的保护作用可能归因于免疫因素。在此，我们回顾文献中的流行病学数据，以支持PIH可能存在免疫基础这一观点。关于细胞和体液机制在PIH病因中的作用、组织相容性的影响以及母胎基因型之间的相互作用，文献中有相互矛盾的报道。最后，讨论了妊娠高血压综合征和流产存在共同免疫病因的证据。
