Bona G, Gallina M R, Zaffaroni M
Clinica Pediatrica di Novara, Università degli Studi di Torino.
Ann Ist Super Sanita. 1994;30(3):329-33.
Transient neonatal hypothyroidism (TH) is a state biochemically characterized by altered TSH and T4 values at screening and subsequently confirmed by serum analysis. TH can go or not go along with clinical manifestations of hypothyroidism and evolves to the normalization of the thyroid functional capacity independently of substitutive therapy. In addition to the complete TH the application of screening programs for congenital hypothyroidism has enable to acknowledge partial changes of the thyroid functional capacity in the neonatal age characterized by isolated anomalies of the individual hormonal parameters. Since the incidence of neonatal TH in Italy is remarkably high (the forms of complete TH being not less than 20% of the hypothyroidism cases diagnosed at the screening) we want to provide an overview of the latest acquisitions regarding TH. Finally the indications for treatment of the various forms of TH, a still controversial matter, are considered, in consideration of the primary role played by thyroid hormones on the development of central nervous system in the perinatal age.
暂时性新生儿甲状腺功能减退症（TH）是一种在筛查时具有TSH和T4值改变的生化状态，随后通过血清分析得以确诊。TH可能伴有或不伴有甲状腺功能减退的临床表现，并且在不依赖替代治疗的情况下，甲状腺功能可自行恢复正常。除了完全性TH外，先天性甲状腺功能减退症筛查项目的应用还能够识别新生儿期甲状腺功能的部分变化，这些变化以个别激素参数的孤立异常为特征。由于意大利新生儿TH的发病率相当高（完全性TH的病例不少于筛查时诊断出的甲状腺功能减退症病例的20%），我们希望提供有关TH的最新研究概况。最后，鉴于甲状腺激素在围产期中枢神经系统发育中的主要作用，我们考虑了各种形式TH的治疗指征，这仍是一个有争议的问题。
