Järvinen P
Rheumatism Foundation Hospital, Heinola, Finland.
Arthritis Rheum. 1995 Mar;38(3):381-3. doi: 10.1002/art.1780380313.
To obtain information on the rate of concordance for ankylosing spondylitis (AS) in a population-based series of twins.
AS cases were identified by record linkage of the population-based Finnish Twin Cohort and the nationwide registry for fully reimbursed medications. A clinical examination was performed to establish concordance for AS.
There were 6 monozygotic (MZ) pairs and 20 dizygotic (DZ) pairs with at least 1 member affected by AS. Three MZ pairs and 3 DZ pairs were concordant for the disease. All affected subjects were HLA-B27 positive. The pairwise concordance rate was 50% in MZ twins and 20% in HLA-B27 positive DZ twins (95% confidence intervals 11.8-88.2% and 4.3%-48.1%, respectively).
These results indicate that AS disease expression is largely, but not entirely, genetically based, with a gene or genes other than B27 probably playing a role.
获取基于人群的双胞胎队列中强直性脊柱炎（AS）的一致性率信息。
通过将基于人群的芬兰双胞胎队列与全国全额报销药物登记处进行记录链接来识别AS病例。进行临床检查以确定AS的一致性。
有6对同卵双胞胎（MZ）和20对异卵双胞胎（DZ），其中至少有1名成员受AS影响。3对MZ双胞胎和3对DZ双胞胎疾病一致。所有受影响的受试者HLA - B27均为阳性。MZ双胞胎的成对一致性率为50%，HLA - B27阳性的DZ双胞胎为20%（95%置信区间分别为11.8 - 88.2%和4.3% - 48.1%）。
这些结果表明，AS疾病表达在很大程度上但并非完全基于遗传，除B27之外的一个或多个基因可能起作用。
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