Wick G, Schett G, Amberger A, Kleindienst R, Xu Q
Institute for Biomedical Aging Research, Austrian Academy of Sciences, Innsbruck.
Immunol Today. 1995 Jan;16(1):27-33. doi: 10.1016/0167-5699(95)80067-0.
In contrast to general beliefs, recent data from different laboratories have provided evidence that the first stages of atherosclerosis are of an inflammatory nature. Here, Georg Wick and colleagues suggest that an autoimmune reaction against heat shock protein 60 (Hsp60), expressed by endothelial cells in areas that are subject to increased haemodynamic stress, is the initiating event in atherogenesis. Humoral and T-cell-mediated immune responses against Hsp60 have both been demonstrated early in disease. This inflammatory stage, which is reversible and has even been found in children, may progress into fully developed atherosclerotic lesions, displaying all the classical pathohistological and functional consequences, if additional risk factors such as high blood cholesterol levels, smoking and obesity, are present.
与普遍看法相反，来自不同实验室的最新数据表明，动脉粥样硬化的最初阶段具有炎症性质。在此，格奥尔格·维克及其同事提出，针对热休克蛋白60（Hsp60）的自身免疫反应是动脉粥样硬化形成的起始事件，Hsp60由血流动力学压力增加区域的内皮细胞表达。针对Hsp60的体液免疫和T细胞介导的免疫反应在疾病早期均已得到证实。这个炎症阶段是可逆的，甚至在儿童中也有发现，如果存在高血胆固醇水平、吸烟和肥胖等其他危险因素，可能会发展为完全成熟的动脉粥样硬化病变，呈现出所有典型的病理组织学和功能后果。
