Th1和Th2 CD4 + T细胞在器官特异性自身免疫性疾病发病机制中的作用
Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases.
作者信息
Liblau R S, Singer S M, McDevitt H O
机构信息
Dept of Microbiology and Immunology, Stanford University School of Medicine, CA 94305-5402.
出版信息
Immunol Today. 1995 Jan;16(1):34-8. doi: 10.1016/0167-5699(95)80068-9.
CD4+ T cells play a key role in regulating immune system function. When these regulatory processes go awry, organ-specific autoimmune diseases may develop. Here, Roland Liblau, Steven Singer and Hugh McDevitt explore the thesis that a particular subset of CD4+ T cells, namely T helper 1 (Th1) cells, contributes to the pathogenesis of organ-specific autoimmune diseases, while another subset, Th2 cells, prevents them.
CD4 + T细胞在调节免疫系统功能中起关键作用。当这些调节过程出现差错时，可能会引发器官特异性自身免疫性疾病。在此，罗兰·利布劳、史蒂文·辛格和休·麦克德维特探讨了这样一种观点：CD4 + T细胞的一个特定亚群，即辅助性T细胞1（Th1）细胞，促成器官特异性自身免疫性疾病的发病机制，而另一个亚群Th2细胞则起到预防作用。
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