Neave N, Lloyd S, Sahgal A, Aggleton J P
Department of Psychology, University of Durham, UK.
Behav Brain Res. 1994 Nov 16;65(1):89-101. doi: 10.1016/0166-4328(94)90077-9.
The effects of cytotoxic lesions in either the anterior cingulate cortex or the retrosplenial cortex were compared with those of fornix lesions on three tests of spatial memory. Two of the tasks, delayed nonmatching-to-position and spatial reversal learning, were tested in an automated apparatus. The third task, forced alternation, was tested in a T-maze. Neither anterior cingulate nor retrosplenial cortex damage produced any significant impairment on the three tasks. In contrast, rats with fornix lesions (hippocampal system damage) were markedly impaired on all three tasks. The results, which were considered in the light of proposals for a hippocampal--anterior thalamic--cingulate system that is important for spatial memory, suggest that neither of the cingulate regions involved in this study form a critical subcomponent of this proposed system. It is therefore assumed that the cingulate cortices are only critical for certain classes of spatial problem. It is also suggested that in some previous studies the effects of inadvertent damage to the cingulum bundle may have contributed to the apparent effects of cingulate lesions.
在三项空间记忆测试中，比较了前扣带回皮质或压后皮质的细胞毒性损伤与穹窿损伤的影响。其中两项任务，即延迟位置匹配和空间反转学习，在自动化仪器中进行测试。第三项任务，即强迫交替，在T型迷宫中进行测试。前扣带回皮质和压后皮质损伤在这三项任务中均未产生任何显著损害。相比之下，穹窿损伤（海马系统损伤）的大鼠在所有三项任务中均明显受损。鉴于提出的对空间记忆很重要的海马-前丘脑-扣带回系统，这些结果表明，本研究中涉及的扣带回区域均未构成该提议系统的关键子成分。因此可以假定，扣带回皮质仅对某些类别的空间问题至关重要。还表明，在一些先前的研究中，扣带束的意外损伤的影响可能导致了扣带回损伤的明显效应。
